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How long does it take for tretinoin to work on dark spots? However, it usually takes several months before you’ll see a noticeable improvement in your skin’s clarity and quality after using tretinoin. In one study, researchers observed a clear improvement in skin quality after participants applied topical tretinoin for 84 days.
Does Accutane affect hormones? Isotretinoin influences pituitary hormone levels in acne patients. Karadag AS(1), Ertugrul DT, Tutal E, Akin KO. Several hormones have been linked to the pathogenesis of acne. In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.
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