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What medication helps prevent migraines? Taking nonsteroidal anti-inflammatory drugs, especially naproxen (Naprosyn), may help prevent migraines and reduce symptoms. OnabotulinumtoxinA (Botox). OnabotulinumtoxinA, which is administered by your doctor during an office visit, has been shown to be helpful in treating chronic migraines in adults.
Which antidepressant is best for migraines? There is little evidence that other classes of antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), are effective for migraine prevention.
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